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These patches may be brown, purple, or darker than the surrounding skin

( Glutathione: a key player in autoimmunity, Carlo Perricone, Caterina De Carolis, Roberto Perricone, Autoimmunity Reviews, 2009, doi: 10.1016/j.autrev.2009.02.020., ( Effect of Glutathione Infusion on Leg Arterial Circulation, Cutaneous Microcirculation, and Pain-Free Walking Distance in Patients With Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Enrico Arosio, MD, Sergio De Marchi, MD Massimo Zannoni, MD, Manlio Prior, MD, Alessandro Lechi, MD, Mayo Clinic Proceedings, DOI: (

All statistical analyses were performed using GraphPad Prism 7d (La Jolla, CA)

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Roughly half of users stop within a year, 5 though persistence has improved to 63% when supply and coverage issues are addressed