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It is important to note that GLP-1 receptor agonists are prescription-only medicines in the UK, regulated by the Medicines and Healthcare products Regulatory Agency (MHRA), and should only be used under medical supervision as part of a comprehensive weight management programme

Pica behavior is a validated endpoint to assess the ability of a compound to induce nausea/malaise in non-vomiting species, as mouse, based on the monitoring of non-nutritive (kaolin) food intake, as an index of gastrointestinal discomfort 43,44

Medicare Utilization of GLP-1s Rises with Broader Indications Beyond Obesity Since Medicare does not cover anti obesity drugs when prescribed solely for weight management, utilization of weight loss indicated GLP-1s historically lagged behind their use in commercial markets

Furthermore, GLP-1 RAs appear to exert direct anti-inflammatory and anticancer effects by activating metabolic sensors, such as the AMPK pathway, to inhibit proliferative signaling