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As was previously mentioned, levels of GH and IGF-1 steadily decrease over a lifespan, and with the lower hormone levels comes a myriad of side effects such as increased fat mass, cardiovascular dysfunction, decreased muscle mass, and declined cellular protein synthesis

WNT--catenin signalling - a versatile player in kidney injury and repair

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PubMed, Martchenko, Alexandre, and Patricia Lee Brubaker