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miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer

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First, although we identified significant alterations in pathways such as fatty acid -oxidation and PPAR signaling, we lacked direct functional validation through experiments such as mitochondrial respiration assays, gene expression analysis of key regulators (e.g., PPAR target genes), or isotopic tracing of fatty acid oxidation

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