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ALA seems to easily make its way into the brain by passing the blood-brain barrier, where it can protect delicate brain and nerve tissue

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While natural GLP-1 is quickly broken down, synthetic analogues like semaglutide have been developed with extended half-lives to make once-weekly dosing possible

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If you are escalating from 2mg to 4mg and want to try split dosing, recognize that you may be spreading the dose below the glucagon threshold