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Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs)along with the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RA tirzepatideare widely acknowledged for their efficacy in managing both type 2 diabetes mellitus and obesity, with expanding indications in cardiometabolic risk reduction

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At Cape Fear Physical Medicine and Rehab, we understand that weight management can be challenging, especially when traditional methods like diet and exercise havent delivered lasting results

Kent, M

TGR5 has been shown to induce the expression of GLP-1,thereby promoting insulin secretion [46, 61, 100]