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GLP-1R agonists were initially used to treat T2DM and soon after it was found that these drugs possess many other physiological properties, such as neuroprotection, neurotrophic, and anti-inflammatory effects, which may be useful to slow the progression of AD ( Figure 3 ) ( Figure 3 Anti-inflammatory effects Previous studies have shown that GLP-1R mimics have anti-inflammatory effects in the CNS (139141)

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21 At the neural level, GLP-1RAs activate CCK-expressing neurons in the NTS and area postrema, brain regions associated with appetite suppression and nausea

Cold Spring Harb Perspect Biol 2(6):116

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