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Sciannimanico S, Grimaldi F, Vescini F, De Pergola G, Iacoviello M, Licchelli B, et al

PRM data were processed with Skyline (21.2.0.425) 46 and normalized to metabolite data

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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

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