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Current PCOS guidance recommends effective contraception with GLP-1 receptor agonists because pregnancy safety data are lacking

Novo is locked in a close race with Eli Lilly to bring the first weight-loss pill to the market

Saxenda was the first to be approved in 2014, followed by Wegovy in 2020 and Zepbound in 2023

Key Takeaways Mazdutide is a dual GLP-1/glucagon agonist: Developed by Innovent Biologics, it activates GLP-1 and glucagon receptors but NOT GIP Tirzepatide is a dual GLP-1/GIP agonist: FDA-approved compound activating different second receptor than Mazdutide Retatrutide is a triple agonist: Activates all three receptors (GLP-1, GIP, and glucagon) for most comprehensive coverage Glucagon receptor activation distinguishes Mazdutide: Different metabolic pathway from Tirzepatide despite both being "dual agonists" Regulatory status differs: Tirzepatide is FDA-approved