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For example, Kuroki and colleagues found that exendin-4 administration would inhibit the matrix metalloproteinase-9 activation in the animal model, with the suppressing effects persisting at least 7 days [4]

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4A, B, SP upregulated the expression of SOD2, HO-1, NRF2, GPX1, and GPX4, while it downregulated the KEAP1 dose-dependently in macrophages