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In human thyroid cancer, GPx3 is frequently methylated, and the expression of GPx3 is regulated by methylation of the promoter region, and this methylation is related to tumor size and lymph node metastasis through the inhibition of Wnt/-catenin signaling [100]

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An important aspect of GSH metabolism in fungus-infected plants is the detoxification of fungal toxins (mycotoxins) by GSTs of host plants