Many studies speculated that the loss of contact with PCs is one of the reasons for the death of IO neurons and other neurons including GCs, basket cells, and stellate cells [70, 72, 76,77,78]
Although these analyses are not specific to the central nervous system (CNS), they do offer clues to ongoing brain injury pathogenesis, as the increased permeability of the bloodbrain barrier (BBB) after TBI allows for greater exchange of CNS/peripheral solutes, and many of these metabolites are also detected in the brain parenchyma [34]
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