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CASE STUDY ANSWER Sixty-seven percent of total standard digoxin clearance is renal, so the standard renal clearance is 0.67 9 L/h = 6 L/h/70 kg with creatinine clearance of 100 mL/min and nonrenal clearance is (1 0.67) 9 L/h = 3 L/h/70 kg (see Table 31 for standard pharmacokinetic parameters)