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It's crucial to discuss medical history and potential risks with a health care provider before using these medications, as these drugs are not suitable for people with certain medical conditions, including those with a history of medullary thyroid cancer, type 1 diabetes, pancreatitis, or severe gastrointestinal disease

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Lee, R.G., et al., Efficacy and safety of an investigational single-course CRISPR base-editing therapy targeting PCSK9 in nonhuman primate and mouse models