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Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome

While not absolutely contraindicated, combining topiramate and tirzepatide increases risks of dehydration, electrolyte abnormalities, and kidney stress

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The phase 2 trial showed 17.1% average body weight reduction at 48 weeks with the 4mg dose