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Eur J Immunol 32:286673, PMID: 12355439 Palomares T, Alonso-Varona A, Alvarez A, Castro B, Calle Y, Bilbao P (1997) Interleukin-2 increases intracellular glutathione levels and reverses the growth inhibiting effects of cyclophosphamide on B16 melanoma cells
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Notably, unexpected AEs such as incorrect dosing, off-label use, extra doses, inappropriate administration schedules, and elevated blood glucose levels were also frequently reported
They used a mouse model of diet-induced obesity and combined metabolomic analyses in BAT and other tissues with stable-isotope tracer studies to answer this question
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