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Frozen single-use aliquots at minus 20C can extend usability to around 90 to 120 days, though potency still drops slightly each week

Choi, S., Nah, S., Jang, H.-D., Moon, J

This zone maintains the most consistent temperature with the least variation from door openings or cooling cycles

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This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]