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19 Furthermore, a study combining 585nm PDL with 1064 nm Nd:YAG without concomitant isotretinoin use reported mild side effects of erythema, dryness, and pain which were also minimally seen in the present study

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The combined treatment downregulates the activity of the anti-apoptotic molecule Bcl-2, upregulates the expression of the pro-apoptotic molecules P53 and Bax, and increases the activity of caspases to promote endogenous apoptosis