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Methyl donor supplementation could modify DNA methylation and subsequent changes in genes responsible for reproducing enzymes involved in de novo hepatic lipogenesis, such as fatty acid synthase 28

The American Cancer Society has warned that CoQ10 counteracts with chemotherapy and radiation therapy, making cancer physicians not to recommend during conventional cancer treatment (58)

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Different from the function of most tight junctions (such as occludin, claudin-1, ZO-1), the expression of claudin-2 protein increases the cell bypass permeability, leading to the destruction of the intestinal epithelial barrier and the increase in bacterial translocation and transmission, and then resulting intestinal dysbiosis [90, 91]