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O'ShaughnessyKLSasserALBellKSRiuttaCFordJLGrindstaffRDet al

Clinical cohorts reveal that approximately 40% of AUD patients meet the criteria for MDD during active addiction, with 1520% continuing to exhibit treatment-resistant depressive symptoms after achieving sobriety, suggesting ethanol-induced neurotoxicity may cause irreversible alterations in mood-regulating circuits (McHugh and McBride 2020

These research areas may be relevant to biological pathway discussions, but they do not establish that TB-500 improves plantar fascia symptoms, mobility, running tolerance, flexibility, or sports recovery in humans

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Atorvastatin in G4 demonstrated stronger efficacy in reducing adrenaline levels compared to safflower