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DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45
By mimicking the effects of a naturally occurring hormone called GLP-1, this medication helps regulate appetite, reduce food intake, and promote feelings of fullness
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Marielle Renae De Baun, OMS 2026