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The study, which is the largest and longest of its kind to date, was conducted across 41 countries and included 17,604 participants aged 45 and older who were either overweight or obese

If diarrhea occurs, add soluble fiber (psyllium) and drink plenty of fluids

53 Also, thiazolinediones have some side effects, such as weight gain, edema, bone loss, increased risk of bladder cancer, and cardiovascular complications, which limit their use