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Studies report nausea, flushing, appetite suppression, and sympathetic effects in some experimental models

Candidates typically fall into one of two groups: patients already running a broader anti-aging protocol who want to add a sleep and cellular renewal layer, or patients whose primary complaint is poor sleep quality and who want a protocol that addresses the underlying circadian biology rather than just supplementing melatonin

The data were presented as the fold increase of the target gene expression, normalized to the housekeeping gene beta-actin, compared to unstimulated conditions

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J Cereb Blood Flow Metab 37:27562767