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10.1126/science.1259472 Science 43 JhaM

Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney

The primary mechanism involves delivery of copper ions to copper-dependent enzymes that are essential for connective tissue repair: lysyl oxidase, which crosslinks collagen and elastin fibers to create structural tensile strength

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It is especially important for the proper function of hematopoiesis, is involved in the synthesis of DNA and ATP, and is necessary for the proper function of the nervous system and for certain metabolic processes in the body