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The EMA's Pharmacovigilance Risk Assessment Committee (2024) has not established a causal association to date, but monitoring continues

ii) Cardiovascular death: Excluding the SOUL trial strengthened the effect (shifting from non-significant to significant), suggesting sensitivity to SOUL but moderate robustness due to consistent overall effect direction and magnitude

Adding complementary medications Anti-nausea medications like ondansetron can be taken on injection days to blunt the GI response

The key is progressive overload, gradually increasing difficulty over time, and consistency, maintaining regular sessions rather than sporadic intense workouts

According to research by Circana, GLP-1 users seem to follow a predictable food-spending trajectory over their first year on the drug