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Zhao L, Cheng Z, Lu Y, Liu M, Chen H, Zhang M, et al
Possible reasons include underdosing, habituation, or metabolic resistance
The sodium excretion, glycemic correction, and gastric slowdown causing the headaches are the same mechanisms driving weight loss and metabolic improvement
Some patients report that taking semaglutide after eating something light rather than on an empty stomach helps with tolerability, though this is based on patient experience and not an official recommendation
Common and Distinct Adverse Effect Profiles Both tirzepatide and semaglutide share gastrointestinal adverse effects as the primary tolerability concern during dose escalation
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