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Nonetheless, the tirzepatide effect of delayed gastric emptying was found to significantly reduce oral contraceptive PK by ~ 60% and, thus, the drug label advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation

Systemic symptoms : Fever, chills, malaise, or other systemic symptoms accompanying injection site reactions require medical assessment to rule out infection or hypersensitivity reactions

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