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observed an elevated sperm count and enhanced semen concentration in a controlled trial with 103 infertile and 107 fertile men who had consumed 5 mg folic acid and 66 mg ZnSO 4 per day for 6 months, either alone or in combination but no enhancements in any of the sperm parameters, most notably concentration were observed [116]

32 Similarly, an association between elevated homocysteine levels and cognitive impairment has been noted, but subsequent vitamin B 12 replacement does not have preventive or therapeutic benefit

The clinical use case is narrower and depends heavily on the patients specific picture