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Guideline document continuation criteria for GLP-1 mimetic therapy in type 2 diabetes

Sources Rebouche CJ

Both surrogate measures are based on fasting levels of plasma insulin and glucose

Morieri ML, Candido R, Frontoni S, Disoteo O, Solini A, Fadini GP (2023) Clinical features, cardiovascular risk profile, and therapeutic trajectories of patients with type 2 diabetes candidate for oral semaglutide therapy in the Italian specialist care

A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)