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GLP-1 suppressed MG-induced beta cell apoptosis through protein kinase A (PKA) and PI3K dependent pathway, respectively It has been reported that activation of GLP-1 receptor by exendin-4 inhibits hydrogen peroxide-induced apoptosis of MIN6 cells in a cAMP- and PI3K-dependent manner with upregulation of Bcl-2/Bcl-xL and downregulation of PARP 19

PloS Genet (2009) 5(6):e1000508

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Although its clinical development is still in early phases, available evidence from adult populations suggests favorable efficacy and tolerability profiles