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L-lysine and L-methionine are used as substrates in human biosynthesis [11]

Regulation of the Immune System: Research indicates that IGF-1 LR3 influences the immune system by regulating cell cycle progression, apoptosis, and protein translation through IGF-1 receptor (IGF-IR) signaling

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Therefore, a critical issue for nerve regeneration and functional reconstruction is to inhibit the glial scar formation

Other criteria such as the Bradford Hill criteria should also be considered (Shimonovich et al., 2021), but this would also suffer for determining a single cause of AD due to the heterogeneity of the AD etiology