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Constipation may remain a long-term issue for some manageable with adequate fibre, water, and movement

Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in HIV-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials

Serious but rare risks (both medications): Pancreatitis Gallbladder disease Acute kidney injury (in severe dehydration cases) Black box warning: Both carry a thyroid C-cell tumor warning based on rodent studies

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highlight that this sequence incorporates several carefully designed amino acid substitutions that may support stability and resistance to enzymatic degradation: (1) At the second position, there is a substitution with D-alanine, possibly offering protection against rapid cleavage by dipeptidylpeptidase-IV (DPP-IV), a key enzyme involved in the degradation of endogenous GHRH