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The metabolic changes that occur as a result of diabetes (hyperinsulinemia, hyperglycemia, and dyslipidemia) potentiate signaling pathways and may increase the oncogenic nature of breast tissue through accelerating cell growth and migration, angiogenesis, increasing metastasis, and decreasing the response to chemotherapy (158, 244247)

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You can't derive dose equivalency from a single weight-loss outcome without controlling for receptor occupancy, dose-response curves, and individual variation

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Frequent use can significantly lower your natural levels