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Clinical trials have shown that Semaglutide can reduce the risk of major cardiovascular events, such as heart attack and stroke, in patients with Type 2 diabetes

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160,161 For example, HM15211, a triple agonist developed by Hanmi Pharmaceutical in South Korea that activates GLP-1R, GIPR and GCGR has entered early clinical trials for the treatment of obesity and non-alcoholic steatohepatitis (NASH)

Like semaglutide, tirzepatide mimics gut hormones that regulate appetite and blood sugar, but it goes one step further by activating both GIP and GLP-1 receptors

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