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2 Exhibit 1: US market penetration vs projected market size In the most recent wave of developments, Novo secured an FDA label expansion for Wegovy for cardiovascular risk reduction (a key step toward medicalizing reimbursement beyond cosmetic weight loss) and, importantly for premiumization, also announced approval of a once-daily oral Wegovy option potentially widening adoption among injectionaverse patients while intensifying competition in convenience-led segments

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Some studies have suggested that it may improve heart health, brain function, and immune function

The benefits are clear

However, it is important to note that there is no official clinical evidence establishing that GLP-1 medications impair pancreatic enzyme production or secretion