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An upregulation of KYAT1 and AADAT may reflect a compensatory astrocytic response to diminished KYNA availability, whereby upregulation of KAT enzymes and glutamate uptake mechanisms attempts to restore NMDAR inhibition and stabilize glutamatergic tone

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Semaglutide is approved for multiple indications, including the treatment of type 2 diabetes (under the brand name Ozempic) and for weight management (under the brand name Wegovy)

Increased levels of iron have been confirmed in the PD midbrain, which in turn results in iron-induced oxidative stress and neurodegeneration (Chinta and Andresen 2008)

One trial evaluated the use of OZEMPIC 2 mg once weekly