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Paeoniflorin and melatonin may stimulate mitophagy by upregulating PINK1 and Parkin, enhancing lysosomal fusion and mitochondrial turnover (Xu G

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The medication is fast tracked for approval, having received an FDA priority review voucher in November 2025

85 Other drugs that have shown promising effects when combined with vitamin E include pentoxifylline (Pentoxil, Trental) 86 and spironolactone (Aldactone)

Ahn B-J, Yim D-S, Lee D-G, Kwon J-C, Kim S-H, Choi S-M (2011) Teicoplanin dosing strategy for treatment of Staphylococcus aureus in Korean patients with neutropenic fever