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GSH Deficiency and OxS in Aging GSH synthesis occurs in two steps, catalyzed by the enzymes glutamate cysteine ligase (GCL, comprised of catalytic and modifier subunits GCLC and GCLM), and GSS, to form the tripeptide glutathione (-glutamyl-cysteinyl-glycine) (22,23)

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Bone marrow mesenchymal stem cells that silence PD-L1 can upregulate the expression of PTEN, inhibit the Akt/mTOR pathway, induce Treg differentiation, and inhibit intestinal inflammation