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Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: a SUSTAIN study analysis

We selected a representative pathway from the inflammatory and metabolic pathways enriched by either caffeine or EGCG for gene expression traceability

This is due to several factors that differ between the controlled conditions of in vitro studies and the complex biological processes in living organisms, including interactions between different cell types, organ systems, and environmental variables (e.g., gut microbiota or circulation) that can influence how a drug works

In the phase 2 dose-finding trial involving 706 participants, nausea rates varied dramatically by dose