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Drug interactions: Orforglipron's CYP3A-mediated metabolism raises the potential for drug-drug interactions with strong CYP3A inhibitors and inducers

Targeting DUBs: A Novel Strategy for Cancer Therapy DUBs can be divided into six families based on their different structures: ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), ovarian-tumor proteases (OTUs), JAMM/MPN domainassociated metallopeptidases (JAMMs), MachadoJoseph disease protein domain proteases (MJD), and monocyte chemotactic protein-induced protein (MCPIP) (Mevissen and Komander, 2017)

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