In SURMOUNT-1, which enrolled adults with obesity or overweight without diabetes, participants receiving tirzepatide 5 mg, 10 mg, or 15 mg weekly achieved mean weight reductions of 15.0%, 19.5%, and 20.9% respectively at 72 weeks, compared to 3.1% with placebo
Rosenstock, J
This review provides a summary of recent discoveries regarding the physiological role and clinical significance of adiponectin in cardiovascular health
1,3 The most common adverse effects are nausea, vomiting, and diarrhea and will be experienced by about 30% of patients, usually when the dose is increased
However, manufacturer savings programs can bring the cost down significantly: Wegovy starts at $149/month and Zepbound starts at $299/month for the starting dose, though prices increase as your dose goes up