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Part Two: Decreasing DHT By Inhibiting 5-Alpha Reductase Review: Three Levers Of DHT Reduction Remember: in order for dihydrotestosterone (DHT) to form, we need all of the following present: Free testosterone 5-alpha reductase Androgen receptors As a result, this gives us three major levers to reduce DHT levels: decrease 1) free testosterone, 2) 5-alpha reductase, and / or 3) androgen receptors

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However, this mechanism requires the presence of susceptible substrates

Therefore the ability of both Dihexa and Nlel-AnglV to promote spinogenesis was measured by an acute 30 minute application on the final day of culturing (Figure 3E)