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Furthermore, genetic variability influencing serum UA levels may modify susceptibility to PD and AD [23,24,25]

Complete protection from cell death is observed with Fer-1 and several Fer-1 analogs in rat oligodendrocytes deprived of Cys 2 , a model of the pathological process leading to periventricular leukomalacia, while more modest protection is observed in a model of Huntingtons disease and in a model of iron-induced kidney tubule damage [7]

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The currently observed decreases in NT-pro-BNP following treatment with orforglipron (perhaps more convincingly in the obesity study, ~ 19% reduction at highest doses) further suggest a potential for cardiovascular benefit