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In a combined fertility and prenatal and postnatal study in male and female rats at subcutaneous doses up to 0.36 mg/kg/day, which was approximately 50 times the recommended human subcutaneous starting dose of 0.2 Units/kg/day (0.007 mg/kg/day), maternal toxicity due to dose-dependent hypoglycemia, including some deaths, was observed

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However, GLP-1(9-36) has been implicated in hepatic glucose production 5 , glycemic control 6 and glucagonostatic actions 7,8