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Published preclinical and in vitro research has examined its interaction with extracellular matrix remodelling, broad gene-expression modulation, antioxidant and anti-inflammatory pathways, and copper-coordination chemistry in cultured fibroblasts and animal wound models

PIO was the first antihyperglycemic medication that demonstrated beneficial liver effects in a small RCT, which analyzed data from 55 individuals with prediabetes/diabetes and biopsy-proven NASH [48]

The freeze-thaw cycle can damage the peptide structure

Half Life: Unknown

Recent studies have further elucidated their supportive roles in conferring tolerance to abiotic stresses, including salinity, drought, and heavy metals exposure, thus expanding their potential applications