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Persistent chronic synovitis leads to synovial congestion and edema and gradual accumulation of neutrophils and various immune cells in synovial tissue, whereas the proliferation of FLSs and active immune cells in synovial tissue increases the demand for oxygen and nutrient supply, forcing microangiogenesis in synovial tissue and eventually leading to a dysregulated neovascular network and the formation of villi-like proliferating granulation tissue (179181)

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Natural testosterone decline accelerates in the 40s and 50s, and for men who are also carrying excess weight, the aromatase-driven conversion of testosterone to estrogen makes the drop more pronounced

Nature 361, 3139