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Recommendation tiers: (i) Strongly Recommended: GLP-1RAs may be used as time-bounded metabolic optimization before OI or ART, aiming to improve metabolic readiness prior to stimulation and pregnancy planning

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A RCT showed that daily supplementation with 10.78 g of collagen peptide (COLLinstant ) for 6 months could significantly reduce the VAS pain score of knee OA patients (an average reduction of 43.6%, p 70) should be restricted to maintain post-meal blood glucose below 7.8 mmol/L (152)

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