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The question arises if mtDNA mutations will increase in frequency through the effect of human migration

While Nogo-A signaling is mainly associated to myelination and inhibition of synaptic and axonal plasticity in adult mammalian CNS, it has also been found to correlate with numerous homeostatic and pathological mechanisms, such as found in schizophrenia (51), stroke (52), beta-amyloid disease (53), spinal cord injury (54) and amyotrophic lateral sclerosis (55, 56)

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