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Usage is highest among women aged 50 to 64, driven largely by weight-loss and metabolic concerns rather than diabetes alone

K., & Maity, C

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[8] [9] GLP-1 medications work through several complementary mechanisms: Enhancing insulin secretion from pancreatic beta cells in response to elevated blood glucose Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , helping you feel fuller for longer Acting on appetite centres in the brain to reduce hunger and food intake In the UK, commonly prescribed GLP-1 receptor agonists include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), lixisenatide (Lyxumia) and exenatide (Byetta, Bydureon)

Together, these data suggest the elevated liver PSAT1 increases glucose tolerance independent of insulin action