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AAV as a Gene Transfer Vector for the Treatment of Neurological Disorders: Novel Treatment Thoughts for ALS

CASPON Tag and cpCasp2 Protease The caspase-based fusion process (CASPON) tag system, developed by Boehringer Ingelheim, combines a solubility-enhancing tag (T7AC), a specific protease cleavage site (for circularly permuted caspase-2), and a hexa-histidine tag for affinity purification [171,172,173]

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